Molecular Devices
- ImageXpress ULTRA™
Benchtop Size의 Confocal Laser Scanning HCS System
High Throughput Image Screening 에 대응한 자동화 Confocal Laser Scanning System 을 위해
자동으로 이미지를 얻고, 자동으로 분석하는 완벽한 System 입니다.
ImageXpress® Ultra System offers the ultimate solution when crisp, clear images are a priority. Controlled by state-of-the-art
MetaXpress® Software, research-quality images of fixed- or live-cells are captured with high resolution. Diverse samples
can be imaged with excellent signal-to-noise ratio, even when there is a high background, as in homogeneous, no-wash
assays, or when samples are thick such as tissue sections or neurons growing in matrix.
[Images of neurons were acquired and tiled from 6 sites. Each site is a long, continuous scan
capturing a larger area with long neuronal features. Note that the neurites perfectly
align across mutiple sites for easy quatification with our software algorithms]
[Mouse kidney section stained for [Neuronal processes can be measured and
nuclei (blue), actin filaments (green) and quantified with a Neurite Outgrowth Application
plasma membrane (red) ] Module in MetaXpress Software ]
⊙ True laser-scanning confocal system ensures a diverse set of samples can be imaged with excellent signal-to-noise ratio.
⊙ Software configurable detection pinhole provides two orders of magnitude of Z-resolution flexibility (from <1 µm to > 100 µm)
over fixed-pinhole confocal systems.
⊙ Simultaneous or sequential scanning with up to 4 solid state lasers facilitates simultaneous acquisition for optimal speed
performance (up to 4 times faster than single laser). Unique sequential scanning is achieved in combination with high-resolution
z-offset to correct for objective lens-induced chromatic aberrations.
⊙ Fully-automated 100 nm resolution voice coil-driven stages provide positioning accuracy to capture intricate sub-cellular
features as well as monitor long structures, such as neurons, across high-resolution tiled or stitched images.
⊙ Software configurable field-of-view simplifies imaging of large objects like model organisms (C. elegans and zebrafish) and
long structures similar to neuronal processes.
⊙ Industry-leading autofocus option provides fast, reliable focusing with a dedicated 690 nm focus laser and ultra-fast sensors
that will not bleach your sample while decreasing read times up to 5-fold.
⊙ Custom design for screening enables capturing 25,000 wells per day in a 384-well microplate assay with a two color high quality
assay (e.g.,Transfluor® beta-arrestin translocation assay). Lower resolution assays can be performed in excess of 100,000 wells/day.
⊙ 4-position automated objective changer eliminates manual objective changes and allows automated switching of magnifications
during a single experiment.
⊙ Universal plate holder facilitates image acquisition using any clear bottom plate from 6-well to 1536-well, in standard height,
low profile, or low volume.
⊙ Walk-away, 24/7 automation is achieved with the Thermo CRS CataLyst Express robotic plate handling system, enabling users to
schedule multiple runs of one to three batches of 15 plates.